Date: May 3, 2021
Postdoc position on lipid cell biology and metabolism available
We are recruiting a motivated postdoc to join our research group at the Institute of Human Genetics of the University Hospital Heidelberg. The general interest of the lab is in the molecular mechanisms underlying hereditary kidney and metabolic diseases. Most of these diseases are caused by single-gene defects and thereby offer unique opportunities to decipher fundamental regulatory pathways of human development and physiology and to develop targeted diagnostic and therapeutic options. Currently, we have a major interest in studying lipid metabolism in kidney physiology and pathophysiology. Among other experimental models, we use Drosophila as a rapid genetic model to study the cell biology as well as organ crosstalk in lipid metabolism, focusing on the contribution of nephrocytes to the lipid composition in the circulation. Recent publications include Dow et al, Nature Reviews Nephrology, 2022; Jouandin, Marelja et al, Science 2022; Perez-Marti et al, BioRxiv 2021; Marchesin et al, Cell Rep 2020; Bedin et al, J Clin Invest 2020; Goncalves et al, PloS Genetics 2018; Rujano et al, J Exp Med 2017; Gleixner et al, Cell Rep 2014. We combine human genetics with several experimental approaches, including fly and mouse genetics, cell culture, microscopy and biochemistry.
Within the framework of an ERC Consolidator Grant, we now offer an exciting opportunity to work in the Drosophila team within the Nephrogenetics unit. For this, we invite applications from individuals with solid Drosophila background. Prior experience with lipid and kidney research is an advantage but not a prerequisite. The projects will be carried out in a stimulating work environment with scientific collaborations across the Heidelberg life science community, in particular with the Molecular Medicine Partnership Unit (MMPU) between the EMBL and the Medical Faculty.
The successful applicant will have opportunities for gaining mentorship experience via helping to train junior investigators in the group and even leading the Drosophila team. The postdoc will also have the flexibility to tailor projects to their own related areas of interest. He/she will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion). Candidates are expected to be highly motivated and to work independently with a strong work ethic. As we are an international lab, proficiency in English language is a requirement. Applications including a cover letter, a detailed CV including a publication list and contacts of up to three referees should be sent as soon as possible to firstname.lastname@example.org
Kidney, Drosophila, nephrocytes, lipid metabolism, lipoproteins, lipotoxicity, endocytosis, lipid droplets